Napoli vs Pisa Prediction, Betting Tips, Lineups & Odds | 22 Sep 2025

Serie A Betting Preview: Napoli vs Pisa

Napoli host Pisa in this Italian Serie A clash at Diego Armando Maradona, with kick-off set for 02:45 on Tuesday 23 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Will Pisa Keep the Scoreline Respectable?

You can wager Pisa +1.5 on the Asian Handicap when playing Napoli. This means getting odds of 1.96 and a return is on the cards if the underdogs are able to win, draw or lose by a single goal.

Betting on our Asian Handicap selection? Access the updated Stake promo code and read our expert review of the platform before locking in your bet.

Two Teams Defeated in Last Game

Napoli won last time out by a 3-1 scoreline. On the road against Fiorentina at Stadio Artemio Franchi, they made it three wins on the spin. Gli Azzurri enjoyed 47% possession and had eight shots on target, while Kevin De Bruyne, Rasmus Hoejlund and Sam Beukema got among the goals.

Four days ago, Napoli were beaten 2-0 when facing Manchester City away in the Champions League.

Pisa have lost in back-to-back Serie A outings. In a recent home game at Stadio Romeo Anconetani, they were turned over 1-0 by Udinese. The Tuscany side recorded two shots on goal and had 51% possession.

Serie A		G	W	D	L	GF	GA	GD	GD	P
2	Napoli	3	3	0	0	6	1	5	6:1	9
19	Pisa	3	0	1	2	1	3	-2	1:3	1

View Full Table

Napoli have 8 wins and 2 draws, averaging 1.7 goals from 5.2 shots on goal and 14.2 attempts. Antonio Conte's side have averaged 61.0% possession, 534.9 passes and 5.4 corners per match, conceding 0.3 goals and 3.6 corners from 1.5 shots on goal and 8.3 attempts.

Scott McTominay leads the way with 7 goals, Romelu Lukaku has 3, with Kevin De Bruyne and Giacomo Raspadori scoring 2. Matteo Politano is the leading assists maker with 3, while goalie Alex Meret has 8 clean sheets.

Pisa have 4 victories, 4 defeats and 2 draws, averaging 3.4 shots on goal, 10.4 attempts and 1.2 goals. I Nerazzurri average 46.7% possession, 4.3 corners taken and 5.0 corners against them, while 1.1 goals have been conceded from 9.3 attempts and 3.1 shots on goal.

The top scorers have been Stefano Moreo, Idrissa Toure, Alexander Lind and Matteo Tramoni, with 2 goals apiece. Stefano Moreo has managed 2 assists in the last 10 games.

Predicted & Confirmed Lineups

Napoli predicted lineup (4-1-4-1): Alex Meret (GK), Giovanni Di Lorenzo, Sam Beukema, Alessandro Buongiorno, Mathias Olivera, Billy Gilmour, Matteo Politano, Andre-Frank Zambo Anguissa, Kevin De Bruyne, David Neres, Lorenzo Lucca.

Pisa predicted lineup (3-5-2): Adrian Semper (GK), Simone Canestrelli, Antonio Caracciolo, Giovanni Bonfanti, Idrissa Toure, Marius Marin, Michel Aebischer, Matteo Tramoni, Mehdi Leris, Stefano Moreo, M'Bala Nzola.

Napoli vs Pisa Prediction & Betting Tips

Step into Napoli vs Pisa with confidence as we bring you our main match prediction, projected scoreline, key corners betting angle, best player prop picks and a custom-built bet builder.

Match Prediction

Pisa +1.5 on the Asian Handicap are a great betting option at 1.96 on the basis that they can perform well as underdogs for this Serie A encounter. We’re expecting the game to be close.

Plenty of research goes into our football picks. It begins by focusing on the latest Serie A form and knowing the injury situation. The important numbers can then be utilised to help complete the picture.

Key Napoli vs Pisa league stats:

• The +1.5 line has been covered by Pisa in 3 consecutive games.
• The -1.5 line hasn’t been covered by Napoli in 15 of their last 20 games.
• The -1.5 line hasn’t been covered by Napoli in 7 of their last 10 games at home.

Pisa +1.5 Probability

The betting apps are estimating that there is a 51% likelihood of this pick landing a return. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. The bet can be recommended for this precise reason.

If you want to land a big potential return from a small stake, then a Bet Builder could be the way to go. Back Pisa to cover the line in a combination with other selections.

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Our Match Prediction

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Correct Score Prediction

Napoli 1 - 0 Pisa

We’ve picked out a correct score of 1-0 being landed by Napoli. You can secure odds of 5.60 and this provides an alternative way to place a wager.

Player Prop Picks

Corners Prediction

Pisa Over 2.5 Corners

Pisa have been awarded an average of 5.00 corners in the past five games, while Napoli have yielded a corner average of 3.60 in their previous ten matches. There are odds of 1.83 available when it comes to this Team Corners bet and we think Pisa can cover the line.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Napoli

Total

9.00 5.40 3.60

Home

10.20 6.90 3.30

Away

8.60 3.90 4.70

Pisa

Total

9.30 4.30 5.00

Home

8.40 5.60 2.80

Away

7.90 3.50 4.40

Latest Corner Odds

Total Corners

Napoli Corners

Pisa Corners

Most Corners

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Napoli vs Pisa Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Bookies Running Scared of Napoli Win

Napoli are overwhelming 1.26 favourites to win this Serie A clash based on the latest betting odds. The bookmakers afford them a 79% probability of claiming the spoils. Pisa are the 11.50 underdogs, while the draw can also be backed as an alternative.

If you fancy Napoli to be leading at the interval, then you can secure odds of 1.76. Alternatively, there’s the chance to wager on Pisa at 8.50 on the Half-Time Result, with the draw trading at 2.48.

You’re able to back Over 2.5 Goals or Under 2.5 Goals at roughly the same price right now. If you’re expecting at least one team to keep a clean sheet, you might be interested in the 1.48 about Both Teams to Score No.

There are hundreds of markets which means lots of options to find a football bet for the latest Serie A match. The best betting sites leave no stone unturned to provide a first-class service.

Lorenzo Lucca Favourite to Find the Net First

Lorenzo Lucca is the market leader to be First Goalscorer at 4.00 while there’s also the chance to back him to find the net at 2.12.

Napoli Difficult to Beat on Home Soil

Napoli are unbeaten over their previous ten games at Diego Armando Maradona. Gli Azzurri have seven wins and three draws in the last 10 home games, scoring an average of 1.80 goals per match and conceding 0.70.

Pisa have recorded four victories, three draws and three defeats in the previous 10 away matches, netting an average of 1.30 goals per game and conceding 0.90.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Napoli Home Stats		7-3-0	2.50	1.80	0.70	5	5	6	4
Pisa Away Stats		4-3-3	2.20	1.30	0.90	4	6	5	5

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Napoli vs Pisa Lineups & Team News

Be smart with your bets — check the Napoli vs Pisa team news beforehand. We’ll offer the predicted and confirmed Serie A lineups along with the latest injury developments.

Napoli Team Page Pisa Team Page