Santos vs São Paulo Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Série A Betting Preview: Santos vs São Paulo

Santos host São Paulo in this Brazilian Série A encounter, with kick-off set for 07:30 on Monday 22 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Back São Paulo to Frustrate Santos

When São Paulo clash against Santos, we will take the former at 1.94 on the Asian Handicap +0.25. With our stake divided between 0 and +0.5, the visitors look as though they can land a return by swerving defeat.

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2-1 Victory for São Paulo in Previous H2H Clash

Santos drew away from home in their last game. A 1-1 scoreline was played out against Atlético Mineiro. The Fish had the majority of the ball boasting 56% possession and five shots on target, with Tiquinho Soares being the goalscorer.

São Paulo claimed a home win in their previous Série A game. A 1-0 victory occurred against Botafogo. Hernan Crespo's side enjoyed 48% possession and three shots on goal, with Juan Dinenno scoring the winner seven minutes after kick-off.

On Thursday night, São Paulo were beaten 2-0 when facing LDU Quito away in the Copa Libertadores.

Head-to-Head Statistics

São Paulo have not lost to Santos in the past three meetings. Their last clash saw São Paulo land a 2-1 home win. The previous 10 H2H games have resulted in four draws and three wins apiece.

Série A		G	W	D	L	GF	GA	GD	GD	P
7	São Paulo	23	9	8	6	27	23	4	27:23	35
16	Santos	22	6	5	11	21	32	-11	21:32	23

View Full Table

Santos have 3 wins, 4 losses and 3 draws, averaging 1.0 goals from 3.7 shots on goal and 8.3 attempts. The Fish have averaged 49.2% possession and 3.4 corners per game, with the opposition getting 1.8 goals from 5.4 shots on goal, 10.8 attempts and 6.0 corners.

Neymar is the top goalscorer with 3, Alvaro Barreal has 2, with Tiquinho Soares and two other players on 1. The leading assistor is Guilherme Augusto with 2.

São Paulo have 7 victories, 1 defeat and 2 draws, with an average of 1.7 goals from 4.7 shots on goal and 9.9 attempts. Hernan Crespo's men have averaged 55.0% possession, 6.2 corners taken and 3.9 corners against, while conceding 0.7 goals from 2.5 shots on goal and 5.9 attempts.

Luciano Neves is top of the team’s scoring charts with 3, while Gonzalo Tapia, Damian Bobadilla, Robert Arboleda and Andre have 2. Nahuel Ferraresi and Luciano Neves have managed 3 assists in the last 10 games.

Predicted & Confirmed Lineups

Santos predicted lineup (Starter): Guilherme Augusto (GK), Victor Hugo.

São Paulo predicted lineup (Starter): Ferreira (GK), Rodriguinho, Mailton, Sabino.

Santos vs São Paulo Prediction & Betting Tips

This Santos vs São Paulo betting guide features sharp analysis across major markets, including a match prediction, correct score bet, corner kick insight, valuable player prop picks and a strategic bet builder.

Match Prediction

We’ll side with São Paulo +0.25 for this Série A clash, with an attractive 1.94 available. Our verdict is that they’ll perform strongly and the Asian Handicap line looks generous for this outcome.

We’re always focused on the Série A form guide to identify the latest betting trends. When it comes to key players getting injured, that can also have a bearing. The latest stats provide even more information to make a football prediction.

Key Santos vs São Paulo league stats:

• The +0.25 line has been covered by São Paulo in 9 of their last 10 games.
• The +0.25 line has been covered by São Paulo in 4 of their last 5 games.
• The -0.25 line hasn’t been covered by Santos in 4 consecutive games.
• The -0.25 line hasn’t been covered by Santos in 7 of their last 10 games.
• The -0.25 line hasn’t been covered by Santos in 14 of their last 20 games.
• The -0.25 line hasn’t been covered by Santos in 3 consecutive games against São Paulo.

São Paulo +0.25 Probability

According to the best betting sites, our pick has a 51.5% chance of landing a return. However, our experts have this number between 55-60% based on their in-depth research. This is why we regard this as a value bet.

It’s good to consider every option and you can opt to take a larger price when it comes to your pick. Proceed with moving the line until you’re satisfied with the odds.

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Our Match Prediction

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Correct Score Prediction

Santos 0 - 1 São Paulo

There’s the option to wager on São Paulo to win by a 1-0 scoreline. Odds of 7.50 are on offer and this is a correct score bet that should provide plenty of entertainment.

Player Prop Picks

Corners Prediction

São Paulo Over 4.5 Corners

In their past four away matches, São Paulo have covered the 4.5 corners line, with Santos conceding 6.00 corners on average in their last 10 games. The number of São Paulo corners might be larger than the line implies and that means a bet at odds of 2.00.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

9.40 3.40 6.00

Home

10.60 5.50 5.10

Away

10.10 3.00 7.10

São Paulo

Total

10.10 6.20 3.90

Home

9.60 5.30 4.30

Away

10.50 4.70 5.80

Latest Corner Odds

Total Corners

Santos Corners

São Paulo Corners

Most Corners

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Santos vs São Paulo Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Latest Odds Suggest a Close Encounter

This Série A encounter sees Santos available at 2.33 and São Paulo priced at 3.30 for the victory. If you want to back the game to finish level, the bookies have odds of 3.00 about the draw.

There’s sometimes a case for betting on the Draw No Bet market, with Santos available at 1.60 for those who want insurance on their bet. The same applies to opponents São Paulo at 2.23.

The Total Goals price implies that Under 2.5 is the most likely result in this contest. The Both Teams to Score No wager is 1.67 and it’s perfect if you anticipate that one side or more will fail to score by the full-time whistle.

The best football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Série A matches.

Neymar Favourite to Score the First Goal

Favourite Neymar is now available at 4.40 to be the First Goalscorer. You will find similar odds apply when it comes to him scoring the last goal.

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Santos vs São Paulo Lineups & Team News

Avoid surprises — review the Santos vs São Paulo team news before you bet. We’ll share both predicted and confirmed lineups for Série A along with the latest injury news.

Santos Team Page São Paulo Team Page